Abstract
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
MeSH terms
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Coumarins / chemical synthesis
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Coumarins / chemistry
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Coumarins / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Lipoxygenase Inhibitors*
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Molecular Structure
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Structure-Activity Relationship
Substances
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Coumarins
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Enzyme Inhibitors
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Lipoxygenase Inhibitors